Epigenetics London

Epigenetics London is an alliance of biomedical researchers from local research institutes and Western University engaged in epigenetics research.  Its purpose is to build linkages among scientists to enhance research and promote epigenetics initiatives in our community.

Nathalie G Bérubé, PhD

Chromatin structure and function in intellectual disability syndromes and brain cancer
     - CTCF function in the developing brain and in memory and learning
     - Epigenetic effects of MeCP2 deficiency in the mouse CNS
     - The outcome of ATRX loss of function in the mouse CNS on myelination and learning
       and memory
     - ATRX and CTCF function in skeletal development
     - Chromatin structure and DNA damage in gliomas




Dean H Betts, PhD

Microenvironmental regulation of stem function and early embryo development
     - Epigenetic reprogramming of telomerase functions
     - Redox regulation of cell fate determination
     - Extra-telomeric role(s) of alternative splice variants of telomerase reverse transcriptase
     - Epigenetic redox control of cellular aging





Chris J Brandl, PhD

Mechanisms of Transcriptional Regulation in Yeast
     - Regulation of chromatin modifying complexes
     - Structure and Function of the SAGA and NuA4 component Tra1
     - Protein chaperones and gene expression
     - Lipids in gene regulation






Fred A Dick, PhD

Regulation of heterochromatin by the retinoblastoma protein
     - Gene targeted mouse models
     - Interaction with Condensin II in higher order chromatin structure
     - Chromosome structure and integrity
     - Genome instability in cancer






Daniel B Hardy, PhD

The role of the perinatal environment in the long-term epigenetic regulation of metabolism
     - Direct and indirect effects of maternal insults in pregnancy (i.e. hypoxia, nicotine, under
       nutrition) on posttranslational histone modifications of lipid-sensing nuclear receptors
       and their downstream target genes
     - Role of miRNAs in the long-term fetal programming of the liver
     - Effect of neonatal catch-up growth on posttranslational histone modifications and
       miRNA profiles in the liver
     - Identifying safe interventions in neonatal life which alter the epigenetic envrionment and
       reverse adverse metabolic outcomes in adulthood


Shawn S-C Li

Protein methylation in development and cancer
     - Histone modifications in stem cell differentiation
     - Protein methylation in DNA damage response and drug resistance
     - Protein methylome and methylome dynamics







Mellissa RW Mann, PhD

Epigenetic regulation of genomic imprinting in early embryos
     - Effects of assisted reproduction on genomic imprinting
     - Function of imprinted noncoding RNAs in domain imprinting
     - Novel epigenetic regulators of domain imprinting
     - Novel imprinting centers and their evolutionary conservation






Joe S Mymryk, PhD

Exploitation of epigenetic regulation by small DNA tumor viruses
We study how the adenoviral E1A and human papillomavirus E7 oncoproteins target
chromatin modification and remodeling systems to reprogram growth and gene
expression in the infected cell
     Ongoing work includes:
          - Studies of the role of H2B monobiquitination on the cellular type I interferon response
          - Studies of the role of the hBre1 and hPaf1 complexes on viral early gene
          - The role of alterations in chromatin modifications induced by human papillomavirus
            on virally induced head and neck cancers
          - Consequences of the interaction of E1A and E7 with histone acetyltransferases


Christopher L Pin, PhD

Epigenetic reprogramming of pancreatic acinar cells
     - Histone modifications in response to pancreatic injury
     - Epigenetic mechanisms governing pancreatic acinar cell fate and de-differentiation
     - Targeted deletion of Ezh2 in pancreatic acinar cells
     - Transcriptional regulation of exocrine pancreatic development and function





David I Rodenhiser, PhD

Epigenetic regulation of gene expression during tumourigenesis and development
     - Functional consequences of DNA methylation in breast cancer metastasis
     - Defining epigenetic effects of environmental pollutants during embryonic development and